• Description
• Additional information

Ipamorelin (RUO) | Highly Selective GH Secretagogue | ≥99% Purity

Product Specifications

• Product Name : Ipamorelin (Research Grade)
• CAS Number : 170851-70-4
• Peptide Sequence : Aib-His-D-2-Nal-D-Phe-Lys-NH2
• Molecular Formula : C38H49N9O5
• Molecular Weight : 711.868 Da
• Purity : 99% or higher (HPLC Verified)
• Form : Lyophilized Crystalline Powder
• Solubility : Soluble in water or sterile saline
• Target Receptor : Ghrelin Receptor (GHS-R1a)

Disclaimer : For Research Use Only (RUO). Not for human use.

Chemical Identity & Characteristics

Ipamorelin (NNC 26-0161) is a synthetic pentapeptide recognized as the first selective agonist of the GHS-R1a receptor. Developed through a rigorous structural-activity relationship (SAR) program, its design specifically excludes the dipeptide Ala-Trp to eliminate the non-selective endocrine activity found in earlier secretagogues.

• Aib ($alpha$-aminoisobutyric acid) : Located at the N-terminus, this non-proteinogenic residue creates a Steric hindrance that induces a helical backbone conformation, protecting the peptide from enzymatic hydrolysis
• D-2-Nal (D-2-naphthylalanine) : This residue features a bulky, bicyclic naphthalene group that acts as a molecular “anchor” in the receptor’s hydrophobic binding pocket, ensuring high-affinity binding (Ki = 2.3 nM)
• D-Isomer Chirality : The use of D-isomers (D-2-Nal and D-Phe) makes the peptide less recognizable to endogenous proteases, extending its functional half-life to approximately 2 hours in humans.

The Selectivity Paradigm

The defining characteristic of Ipamorelin is its “GH-specific” profile. Unlike GHRP-2 or GHRP-6, Ipamorelin does not induce significant surges in:

ACTH & Cortisol : Even at doses 200-fold higher than the effective threshold for GH release

Prolactin : No meaningful elevation observed in clinical models.

Appetite Stimulation : Does not strongly activate the orexigenic (hunger) pathways associated with GHRP-6.

Research Context & Clinical Insights (2024–2025)

Muscle preservation : In a 12-month trial involving subjects aged 65–80, daily administration resulted in a 4.2% increase in lean body mass, compared to a 0.3% increase in the placebo group.

Skeletal Geometry : Research confirms Ipamorelin increases Bone Mineral Content (BMC) by stimulating true geometric growth of cortical bone dimensions.

Neuroprotection (2024) : Recent studies in Neuropharmacology demonstrate reduced neuroinflammation in animal models of traumatic brain injury (TBI) via GHS-R1a pathways.

Metabolic Syndrome : Observations include an 11.3% reduction in visceral adipose tissue and an 18% improvement in insulin sensitivity (HOMA-IR) over 6 months.

Comparative Selectivity Profile: GHS-R1a Agonists

Chemical identity of Ipamorelin peptide

chemical identity of Ipamorelin peptide (C38H49N9O5) showing the pentapeptide sequence Aib-His-D-2-Nal-D-Phe-Lys-NH2 for high-purity laboratory reference and identification.

Why Researchers Source Ipamorelin from Profound Aminos

Profound Aminos provides the analytical transparency required for institutional-grade research.

Lot-Specific Transparency :
Every shipment includes a verified Certificate of Analysis (COA) with HPLC chromatograms and Mass Spectrometry data, confirming purity of 99% or above.

USA-Based Cold-Chain Logistics:
To prevent thermal degradation, all peptides are stored at -20°C and shipped from our USA facility to ensure immediate experimental potency.

Endotoxin Monitoring :
We screen for endotoxins to < 1.0 EU/mg ensure suitability for sensitive in vitro assays and cellular modeling.

Total Traceability :
Every vial is batch-tracked, allowing researchers to maintain strict quality control in longitudinal studies.

Regulatory & Compliance Statement

FDA Status : Ipamorelin is currently on Category 2 of the Interim Policy on Compounding due to its non-natural amino acid content. It is not FDA-approved for human use.

WADA Status : Prohibited at all times as a Growth Hormone Secretagogue

RUO Designation : This compound is provided strictly for Laboratory Research Use Only.

Frequently Asked Questions

Q: Why is Ipamorelin often combined with CJC-1295?

A: GHRH analogs like CJC-1295 (the amplifier) and GHS-R1a agonists like Ipamorelin (the trigger) act synergistically to produce a massive GH release greater than the sum of their individual effects

Q: Does Ipamorelin require a “refractory period”?

A: Yes. Because it triggers a “dump” of stored GH, the pituitary requires a period to resynthesize hormone stores before another pulse can be triggered

Q: How should it be stored for long-term research?

A: Lyophilized powder should be stored at -20°C to -80°C for 12–24 months of stability.

DISCLAIMER:

• Products sold on our website are meant for scientific research purposes only, designed for in vitro testing and lab experimentation exclusively. These products are not intended to be used as foods, drugs or cosmetics, any sort of bodily introduction of the products into humans or animals is strictly prohibited. They must also not be misbranded, misused, or mislabeled, or used for anything other than research and scientific investigation.
• All the products you see on the website are being sold in a lyophilized powder state (freeze-dried), in a sealed sterile vial; and should be reconstituted.
  The product’s label clearly states the amount of product a vial contains; some products are offered in different variations.
• The products we are selling come in a sealed vial but require additional lab equipment for proper testing. 
• Though we make sure packaging, label, seals and writing does not differ from the product photos you see on our website, there is a chance for a minimal deviation.